Thrombocytopenia

Questions discussed in this category

How do you approach anticoagulation in the setting of HIT and thrombocytopenia?

i.e. platelet count <30. Would your management change if HIT were only suspected rather than confirmed?

At what platelet count would you feel comfortable dosing aspirin 81 mg for coronary artery disease in a patient with ITP?

Presuming strong indication for ASA - eg history of NSTEMI

1 Answer available

To what extent does the degree of thrombocytopenia correlate with the severity of cirrhosis?

1 Answer available

Based on recent data would you consider adding ATRA to low dose rituximab for steroid refractory ITP?

https://doi.org/10.1182/blood.2021013393

1 Answer available

Would you give a TPO agonist for thrombocytopenia in alcoholic cirrhosis?

1 Answer available

How do you approach very treatment-refractory ITP?

Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.

1 Answer available

How do you manage drug-induced thrombocytopenia when the implicated drug is essential?

e.g. DITP from eptifibatide after a cardiac intervention

1 Answer available

For treatment of ITP, what would you add to dexamethasone to achieve the fastest recovery in a patient waiting for a procedure?

IVIG, TPO, or other agents?

1 Answer available

Do you routinely check platelet counts after COVID-19 vaccines in patients with chronic ITP?

1 Answer available

With what agents can you replace PPIs if they cause thrombocytopenia?

1 Answer available

Should platelet transfusions be considered for anti-platelet agent reversal in patients with major bleeding?

1 Answer available

How long do you continue caplacizumab in relapsed refractory TTP?

How often do you monitor ADAMTS-13 levels off therapy?

1 Answer available

Are there any reasons to consider a prolonged course of steroids with taper over a shorter course of pulsed steroids in the treatment of ITP?

For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?

1 Answer available

How do you approach the treatment of drug-induced thrombotic microangiopathy?

When do you consider initiating eculizumab?

1 Answer available

What is your approach to platelet transfusion in heparin induced thrombocytopenia?

Does having a concurrent consumptive process e.g. DIC change your management?

1 Answer available

How would you advise patients with known stable autoimmune thrombocytopenia regarding the Ad26.COV2.S (Johnson & Johnson/Janssen) vaccine?

1 Answer available

When (if ever) do you check for anti-platelet antibodies for workup of thrombocytopenia?

1 Answer available

Is there a role for prophylactic tranexamic acid in patients with hematologic malignancy with chemotherapy-induced thrombocytopenia?

1 Answer available

How do you approach the treatment of ITP in a pregnant patient who did not respond to prednisone?

Would you consider high-dose dexamethasone (deliberating adverse effects of antenatal steroids) or move to next-line therapies?

1 Answer available

What is your approach to treating refractory thrombocytopenia in lupus?

2 Answers available

How do you manage thrombocytopenia when radiating the spleen?

At what point would you recommend transfusion? At what point would you stop radiation?

1 Answer available

When should you use caplacizumab in the treatment of acute TTP patients?

1 Answer available

Papers discussed in this category

Blood, 2015 May 13

A novel triple therapy for ITP using high-dose dexamethasone, low-dose rituximab, and cyclosporine (TT4).

Blood, 2009 Nov 06

Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura.

Blood,

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance.

J Pharm Pract, 2019 Mar 27

Lansoprazole-Induced Thrombocytopenia in a Critically Ill Patient: A Case Report.

Thrombocytopenia

Questions discussed in this category

Papers discussed in this category

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