Assuming that a thorough work up for other causes of fatigue (anemia, thyroid dysfunction, sleep apnea, etc) has been performed and is negative, no single medication has been proven by a randomized placebo-controlled trial to help chronic fatigue in PASC. Anecdotally, my colleagues who treat PASC ha...

Treat insomnia if present (Melatonin, etc) and attention to sleep pattern Vit D Fish oil Magnesium CoQ10 Rule out Myalgia Myopathic Syndromes, EDS and other Collagen Connective tissue disorders, Spondylosis, Lyme, and other tick-borne disorders EBV, etc Low dose Modafinil Low dose Ritalin or A...

I am making two assumptions in formulating my answer to this question: (1) Fatigue in long Covid (post-acute sequelae of SARS-CoV-2 infection, or PASC) is often just a starting point for discussion of what is typically a multi-system disorder manifesting a great deal of heterogeneity; and (2) as alr...