Cyclophosphamide (CYC) is an alkylating agent primarily used in the treatment of malignant lymphomas, and its gonadotoxic properties are well-established. CYC can cause ovarian toxicity via follicle atresia and granulosa cell apoptosis in females as well as oligospermia and azoospermia in males. In ...

I am not a pediatric rheumatologist so I would need to defer to a pediatric rheumatologist regarding this question. However, the Euro lupus protocol 500mg q two weeks x 6, has not been shown to significantly reduce fertility. Moreover, impairment of ovarian function after cyclophosphamide therapy is...