Is there experience/reports of using voxelotor in sickle cell patients who are Jehovah Witnesses with few crises but who have fatigue and/or dyspnea?

Topics: Pediatric Oncology • Medical Oncology • Hematology • Sickle Cell • Pediatric Hematology • Benign Hematology

Also is there value in using voxelotor for the purpose of reducing hemolysis, and if so what parameters do you use to determine when to initiate voxelotor with that goal in mind?

Answer from: at Academic Institution

I would not hesitate to use voxelotor in most patients with sickle cell anemia, including Jehovah's Witnesses, if they have not responded to hydroxyurea with near cessation of acute vasoocclusive events and have continued hemolytic anemia. Voxelotor usually reduces hemolysis that results in an incre...

Comments

at Dana-Farber Cancer Institute
I fully agree with Dr. @Martin H. Steinberg.

Answer from: at Community Practice

Agree with Dr. @Martin H. Steinberg. The below article provides retrospective evidence of reduced transfusion requirements with Vox during the pandemic. We have seen significant increase in Hgb in patients with multiple allo antibodies who cannot be transfused so we would extrapolate that a similar ...

Related Questions