In which clinical scenarios is relying on the urine protein-to-creatinine ratio as a measure of proteinuria unreliable, and interpretations should be made looking at urine protein and urine creatinine separately?

Topics: Rheumatology • Nephrology

Answer from: Medical Oncologist at Community Practice

I typically only use spot UPCRs because (1) they are easy to obtain and thus trend (2) they account for BSA indirectly because it accounts for Cr excretion. The best role of urine protein measurements is really just to trend if your therapy is effective or to screen for disease. When looking at urin...

Comments

at Uniformed Services University of the Health Sciences (USUHS)
It is very nice to hear a nephrologist's perspecti...

at University of Colorado School of Medicine
Thanks, Dr. @Yau! When using albumin:creatinine ra...

Medical Oncologist at Ohio State University Medical Center
@Jason Kolfenbach Yes, you are correct. The remiss...

at Duke University Medical Center
Thanks for the great follow-up question @Jason Kol...

at Medical University of South Carolina
I trend UPCRs in almost all of my lupus patients, ...

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