How would you treat a newly diagnosed male with metastatic HR+ breast cancer?
Do you give first line CDK 4/6 inhibitors with Tamoxifen or Aromatase Inhibitor (+/- GnRH analogue)?
Answer from: Medical Oncologist at Academic Institution
I would recommend CDK 4/6 with AI and GnRH analog.There's no clear evidence from studies since male breast cancer is rare (<1% of breast cancers), and most CDK studies did not include male patients. There is one case report published recently in Mol Clin Oncol Feb 2020.FDA approved palbociclib fo...
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