Neurology

NCCN lists PCV as category 1 (and now with analysis in Abstract 2002 from ASCO 2019 showing benefit in IDH mutated), and temozolomide as 2B, yet temoz...

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What are your recommendations for a patient with metastatic non-mutated lung adenocarcinoma who previously had headaches responsive to prednisone but with negative temporal artery biopsy for GCA?

For medical oncologists, would you offer a PD-1/L1 inhibitor? For other subspecialties, how would you counsel the oncologist regarding the risk of usi...

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How do you approach the workup of a patient with incidentally found pachymeningitis?

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How would you approach treatment of a brainstem AVM after hemorrhage in a patient not a candidate for surgery or embolization?

What would be your preferred technique and dose/fractionation?

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What is the appropriate workup and treatment for patients with SMART syndrome following radiation for brain tumors?

For stroke-like migraine attacks after radiation therapy (SMART syndrome), does your management of these patient's change with recurrent episodes? How...

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What is the best course of action for a patient with isolated carcinomatous meningitis who is responding well to intrathecal methotrexate but now has MRI findings suspicious for methotrexate leukoencephalopathy?

Can intrathecal methotrexate be continued with close neurologic observation vs switch in treatment now due to findings?

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Do you ever use bevacizumab in combination with standard radiation and temozolomide in the first-line setting for patients with glioblastoma?

If so, when do you consider this?

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How do you approach patients with suspected CNS lymphoma who have been treated with steroids?

Do you biopsy immediately, stop treatment, biopsy at a later time, or depend solely on the data you already have?

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How do you manage a symptomatic meningioma and associated vasogenic edema in a poor performance status patient?

Is there any additional benefit to radiation in addition to steroids in a patient who is not a surgical candidate?

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How do you manage multiple cavernous malformations that have bled and enlarged over time?

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How do you counsel patients on control of glioma-related seizures following radiation?

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How do you approach treatment of 1p19q non-codeleted high grade gliomas?

Has the recently published interim analysis of the CATNON trial altered your utilization of temozolomide? Does IDH status change your treatment appro...

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Is it ever appropriate to omit temozolomide in unmethylated glioblastoma?

Do you consider the small, but statistically significant, improvement in OS to outweigh the side effects of treatment?

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How do you approach treatment of a glioblastoma in pregnancy?

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How do you manage incidentally identified pituitary lesions on brain imaging?

What workup do you typically recommend?

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Is placing a VP shunt a major risk to spread medulloblastoma or other malignant brain tumors into the gut?

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In a healthy patient >65 years of age with glioblastoma multiforme, what is the recommendation for temozolomide when given concurrently with adjuvant radiation therapy?

Length of temozolomide course when given with adjuvant radiotherapy

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How would you manage leptomeningeal disease of the spine in the setting of prior WBRT?

What factors play into your decision whether to re-treat the brain with craniospinal radiotherapy vs irradiation of the spine only vs other measures (...

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In what situations would you consider memantine when treating multiple brain metastases with SRS?

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What is the optimal management for a patient with Tourette Syndrome with severe tics that preclude the patient from lying still for radiation?

E.g. The case in question is for a patient planned for thoracic RT for LS-SCLC. Any medications that may help or just give much bigger expansions to c...

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How do you approach treatment of a spinal meningioma?

When do you favor RT? What is your preferred dose/fractionation?

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How do you do approach treatment of a recurrent gliosarcoma?

How does length of time from prior chemoradiotherapy influence your management?

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How do you manage cranial radiotherapy in the setting of an acute CVA?

In a palliative setting, how long would you wait to initiate WBRT?

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