Her2-negative breast cancer

Questions discussed in this category

If you have a high risk HR+, BRCA+ breast cancer patient who qualifies for adjuvant olaparib and abemaciclib, which one would you give and why?

Would you ever consider using these in sequence?

4 Answers available

How and on which specimens will you perform Ki-67 testing in newly diagnosed breast cancer?

Should this be sent on initial biopsy or on surgical pathology? What if an initially high risk patient has good risk findings post-operatively?What ha...

4 Answers available

How do you incorporate oncotype Dx recurrence score when planning adjuvant CDK 4/6 inhibitor for high risk early stage HR+ breast cancer?

1 Answer available

How do you view the use of adjuvant CDK4/6 inhibitors overall given discordant results between MonarchE and PALLAS?

Are there factors to explain why MonarchE was a positive study and PALLAS was not?

4 Answers available

How far can you dose reduce abemaciclib for a patient who is having toxicity at starting doses?

Can you use 50mg BID if intolerant to 150mg and 100mg dosing? Any tips for side effect management to help patients stay on full duration?

5 Answers available

Will you offer adjuvant abemaciclib to breast cancer patients with high Ki-67 who are unable to receive perioperative chemo due to comorbidities or who decline chemotherapy?

Majority of patients on MonarchE received neoadjuvant/adjuvant chemo. Does the availability of abemaciclib impact your decision to offer chemo ...

3 Answers available

Does the magnitude of benefit with 2 years of adjuvant abemaciclib outweigh side effects, given that many patients will receive CDK 4/6 inhibitors at breast cancer recurrence, precluding OS benefits?

MonarchE shows statistically significant improvement in IDFS and DRFS, but the magnitude of absolute benefit is modest (3-year IDFS and DRFS rates = 5...

5 Answers available

Would you offer adjuvant abemaciclib + an aromatase inhibitor to a patient with a local HR+HER- breast cancer reoccurrence while on tamoxifen that meets high-risk criteria?

High-risk criteria meaning >4 positive nodes and Ki67 >20%

3 Answers available