Questions discussed in this category
The disease is responsive to ablative lasers however laser treatments are not an option.
Does your evaluation hinge on nonresolution with warming? How extensive is your workup?
If not, what tumor characteristics prompt you to collect debulking specimens for paraffin or frozen section staining?
Does morphology guide your workup?
And what factors push you towards the selection of a specific treatment modality?
Would starting spironolactone be a good option?
In your experience, do specific patient features predict a better response?
Would a history of immunosuppression impact your decision?
For example, in the setting of cirrhosis incidentally found on imaging.
Especially in the setting of these being more narrow acting than tofacitinib, should we consider them safer than our old drugs?
For kids experiencing moderate to severe urticaria that improve with single-dose antihistamine, do you scale up the manufacturer packaging dosages up ...
Have you prescribed Rituximab and IVIG simultaneously for patients?
Do you use any compounded topical therapies?
Mycosis fungoides and Sezary syndrome are thought to be distinct genotypically and phenotypically. It is my understanding that Sezary syndrome typical...
Other than inflammatory markers and following symptoms/exam, do you need any other specific monitoring for progression to systemic disease?
Do you prefer restarting the biologic with the loading or maintenance dosing?
Would you switch to itraconazole or perform fungal cultures?
Do you have a preferred sequence of therapies for diffuse skin limited MF?
Are there specific cases where you would or would not consider early flap division?
Assuming it has previously been treated with excision and steroid injections? Is it reasonable to treat a bothersome keloid in a pediatric patient aft...
(Refractory to mycophenolate, azathioprine, and methotrexate. UpToDate suggests thalidomide or IVIG with mixed efficacy, while there are some case rep...
What is the role for surgery vs RT?
Would you offer systemic therapy and/or radiation therapy to groin/pelvis?
Do you attempt to taper fully or maintain at a low dose?
What are your preferred treatment methods other than topical Vitamin E and azole antifungals?
Several speakers at ACR 2021 commented on the important role of drug levels in the management of these patients and cautioned against adding medicatio...
If so, how long after phototherapy (eg. NB-UVB) is it safe to proceed with RT?
See: Systemic review of phototherapy for pruritic skin disorders
Do you obtain vascular imaging routinely in these cases, and if so, do you use cross-sectional or invasive angiography?
In a patient who would be otherwise fit for surgery +/- adjuvant RT, and the delay is caused by COVID-related OR staffing issues, what would be your a...
In other words, do we think of TNFi induced lupus and TNFi induced psoriasis as a drug effect or a class effect?
Is there any alteration in approach from the medical, surgical, or radiation oncology perspective that can mitigate the risk of forming keloids withou...
Would you change rituximab maintenance dose or schedule?
Specifically: starting dose, rapidity of up-titration, frequency of lab monitoring, frequency of office visits, and timing of assessment for treatment...
What is the role and sequence of surgery and/or RT?
Which nodal levels would you include in your RT field(s)?
Muscle disease is quiescent and no other manifestations such as ILD
In the ADVOCATE trial, patients were not re-dosed with rituximab.
E.g., MPO vs PR3, newly diagnosed vs relapsed, renal involvement. Acknowledge that the ADVOCATE study was not powered to detect these differences, but...
What if the patient has MGUS?
Do patients with type 1 cryoglobulins need a bone marrow biopsy as part of the work up?
Post-auricular cutaneous angiosarcoma, pT1 (19 mm) with negative margins. Unclear if there is any indication for systemic therapy, given early stage a...
What approaches (surgical vs non-surgical) offer the best cosmesis for keratoacanthoma (low grade squamous cell carcinoma) ?
Is there a role for radiation? Does your approach differ depending on site(s) of disease, and/or if the patient has Basal-Cell Nevus (Gorlin) sy...
If so, are there specific patient populations for which you would use this metric?
In general, how would you approach such a case with regards to creation of your treatment volumes and dose-fractionation?
What if pathology showed NED?
Would you recommend radiation therapy or immunotherapy? If proceeding with radiation therapy, what dose-fractionation and technique would you utilize?
What dose-fractionation schedule would you utilize?
When do you electively treat the ipsilateral versus ipsi- and contralateral neck?
This particular case involves a patient with a frontal scalp low grade eccrine carcinoma status-post excision with positive margin complicated by...
If you use both, how do you decide which to use for a particular patient?
Would you recommend locoregional radiation therapy or systemic or immunotherapy alone? If you would consider radiation therapy, what would be your rec...
Would you treat the primary site alone, include the hand and arm lymphatics to the epitrochlear nodes (one continious treatment volume from hand to el...
Given the location but no other high risk features would you offer RT?
If so, what dose and fields?
What pathologic features are most important when evaluating the possible need for adjuvant therapy?
Would you offer RT? If so, shat dose fractionation do you recommend?
*Negative margins, <1cm in size, no LVI, negative SLNB, not immunocompromised, no prior surgery (as well as a negative PET/CT scan).
If so, what is your suggested dose/fractionation?
NCCN lists only substantial perineural invasion. What about other high-risk adverse features such as histologic subtype, multiple recurrences, d...
When elective nodal radiation is recommended, which nodes would you treat (i.e. facial, pre-auricular, peri-parotid, levels I-III, etc.)?
Patient underwent a shave biopsy of a 6x5x2mm preauricular lesion that showed moderatley differentiated sebaceous carcinoma with deep and lateral marg...
What dose/fractionation would yield the lowest risk of graft failure? Does your treatment management change based of location, ex the ear vs back?
If so, how large of a margin would you place on the primary lesion and would you incorporate any adjacent lymph node levels?
Following Mohs surgery and in the absence of other high risk features, do you offer RT for any PNI? A single nerve < 0.1 mm? A single ne...
Would re-irradiation be an appropriate option? What dose/field would you incorporate? If treating with standard fractionation, would you take the enti...
I have seen some patients who may undergo large complex closures (sometimes as a separate procedure) for smaller lesions with resulting scars that sig...
If so, what is your treatment volume?
Is modern surgical/reconstruction treatment superior to radiation therapy?
If contact brachytherapy or superficial (orthovoltage) therapy isnt possib...
99471147913344133431325713289132601229413279132371324313232132401324213208130681313212977109399415130631300012978127301147513016129671292212920129261279712925125651281312868128771217012805114001148512693127611278412471126951269112697126961263711476114981148211801115011148811483125861256612416124871240211486114781245312454124291217110062114911238212381120662840123081224177612125121741148412047120701168157681133011535800611495116691150311697115001150411657116981150211499114971149611494114931149211489114871147711201113201132891961097410637104321046910392103511027510267102181008395308953942294759531952994179421916993489280931188588040929486219010890388318589886288868739657585428686865084858553845785247314847384778355828281187746731781518135811773278071808379317967797679667886781678267322773776927743731376537185526964006379577856484913480133773050286326672260156887613181185873712
Papers discussed in this category
Br J Radiol,
Burns, 2014 Apr 24
Pediatrics, 2013-01
Pediatrics, 2016-02
International journal of radiation oncology, biology, physics, 2018-09-01
Cancer, 1995 May 1
Ann Surg Oncol, 2003 May
American journal of surgery, 2001-12
World J Surg, 1992 Mar-Apr
Cancer, 2005-10-01
Journal of contemporary brachytherapy, 2017-04
Melanoma research, 2015-04
Nature, 2018-01-18
Cureus, 2019 Jun 18
PloS one, 2015
The British journal of dermatology, 2019-02
JAAD Case Rep, 2019 Jun 26
The New England journal of medicine, 2010-07-15
Medicine (Baltimore),
The New England journal of medicine, 2010-07-15
,
, 2016 Aug 30
J. Am. Coll. Cardiol.,
Arthritis and rheumatism, 1982-11
Arthritis and rheumatism, 2012-08
, 2019 Aug 06
Arthritis Rheum.,
Ann. Rheum. Dis., 2018 Apr 25
Ann. Rheum. Dis., 2017 May 25
Ann. Rheum. Dis., 2018 May 03
Medicine, 1976-05
Arthritis and rheumatism, 2010-01
J. Rheumatol., 2019 Sep 01
Pract Radiat Oncol, 2019 Dec 09
Annals of the rheumatic diseases, 2009-03
JAMA ophthalmology, 2014-12
Can J Ophthalmol,
J Am Acad Dermatol, 2016 Feb 03
JAMA network open, 2018-11-02
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2008-10
Clin Rheumatol, 2006 Dec 21
Rheumatol Int, 2020 Sep 18
Arthritis Rheumatol, 2016 Jan
Kidney international reports, 2018-03
N Engl J Med, 2020 Feb 13
Rheumatology (Oxford),
Journal of psoriasis and psoriatic arthritis, 2019-04
Front Pharmacol, 2019 Mar 26
Nat Rev Dis Primers, 2018 Aug 02
N Engl J Med, 2021 Feb 18
Int J Clin Pract, 2021 Mar 24
Mod Rheumatol, 2021 Feb 09
Heart Rhythm, 2020 Jun 28
Arthritis care & research, 2018-03
J Clin Rheumatol, 2020 Sep 18
Cureus, 2020 Aug 02
Ann Intern Med,
Ann Rheum Dis, 2011 Nov 29
Lancet Oncol, 2019 Dec
Respir Med, 2012 Apr 09
Am J Respir Crit Care Med,
Seminars in arthritis and rheumatism, 2010-12
Clin Exp Rheumatol, 2012 Oct 17
Inflamm Bowel Dis,
Am J Clin Dermatol,
Radiographics : a review publication of the Radiological Society of North America, Inc, 2001
International journal of clinical rheumatology, 2010
Lupus science & medicine, 2014
The Journal of rheumatology, 2015-11
Ophthalmology, 2016-06
Lupus science & medicine, 2017
Journal of immunology research, 2017
Lupus science & medicine, 2018
Arthritis care & research, 2019-07
Clin Pharmacol Ther, 2018 Jun
Lupus Sci Med, 2016
Rev Med Interne, 2016 Oct 13
JAMA Dermatol,
Lupus Sci Med, 2016 Feb 01
Lupus Sci Med,
ACR Open Rheumatol, 2020 Oct 12
Arthritis Rheumatol, 2021 May 02
Ann Rheum Dis, 2012 Nov 10
Arthritis Rheum,
Lupus,
Arthritis Rheumatol, 2020 Jan 07
Lupus Sci Med, 2019
Journal of medical case reports, 2010-05-22
Ann Med Surg (Lond), 2017 Jun 20
Case Rep Oncol, 2021 May 10
J Clin Oncol,
Acta Gastroenterol Belg,
Int J Dermatol,
J Am Acad Dermatol,
Br J Dermatol, 2018 Oct 10
Dermatologic therapy, 2018-11
Dermatol Ther (Heidelb), 2019 Nov 20
J Am Acad Dermatol, 2019 Mar 11
J Am Acad Dermatol, 2019 May 13
Dermatology,
Best practice & research. Clinical rheumatology, 2013-06
Dermatol Ther, 2016 Apr 12
The Lancet. Respiratory medicine, 2016-09
Journal of the American College of Surgeons, 2011-04
Am J Surg,
J Immunother Cancer,
Journal of the American Academy of Dermatology, 2011-07
JAMA Dermatol,
J Dermatol,
N Engl J Med,
Minerva Gastroenterol Dietol, 2016 Sep 07
Free Radic Biol Med,
Ann Plast Surg,
Journal of psychiatric practice, 2018-11
Journal of the American Academy of Dermatology, 2019-05
Med Hypotheses, 2006 Nov 28
J Am Acad Dermatol, 2021 Apr 18
Prog Neuropsychopharmacol Biol Psychiatry,
Antimicrob Agents Chemother, 2008 Nov 17
Journal of investigational allergology & clinical immunology, 2007
Int Arch Allergy Immunol, 2018 Sep 25
Eur J Dermatol,
Rheum Dis Clin North Am, 2020 Aug
Rheumatology (Oxford),
Dermatol Clin,
J Am Acad Dermatol, 2014 Sep 19
Br J Dermatol,
East Afr Med J,
Int J Dermatol,
J Pathol,
Sci Rep, 2021 Oct 12
Acta Derm Venereol,
Br J Dermatol, 2019 Sep 18
Br J Dermatol, 2019 Oct 16
The British journal of dermatology, 2019-11
Frontiers in immunology, 2019
J Am Acad Dermatol, 2020 Sep 04
Rheumatology (Oxford),
Case reports in rheumatology, 2017
Contact Dermatitis,
Oral Surg Oral Med Oral Pathol Oral Radiol, 2012 Mar 26
J Am Dent Assoc,
Oral Oncol, 2006 Nov 16
Am J Clin Dermatol,
The American Journal of dermatopathology, 2013-07
The American journal of surgical pathology, 2018-03
The American journal of surgical pathology, 2018-11
Appl Immunohistochem Mol Morphol,
Pathology, 2016 Aug 28
Am J Dermatopathol,
Am J Dermatopathol,
J Am Acad Dermatol, 2022 Jun 23
Dermatol Surg,
Arch Dermatol,