Neurology

Radiation Oncology

Questions discussed in this category

What is your surveillance strategy in patients with brain metastases who are getting systemic therapy?

How often are you scanning the brain and what is your trigger to treat?

3 Answers available

When would you recommend standard of care over hypofractionated treatment in an elderly patient diagnosed with Glioblastoma?

1 Answer available

Is there any evidence that radiotherapy can worsen balance, dizziness, or vertigo in patients treated for vestibular schwannoma due to transient edema?

If so, what percent likelihood do you quote patients for this risk with SRS, SRT and fully fractionated therapy?

2 Answers available

How do you manage TTFields for a patient with glioblastoma in the setting of disease progression?

Do you routinely discontinue the device or continue if they are otherwise tolerating the treatment well?

1 Answer available

Do you take any special precautions when treating cervical spine metastases?

Do you require neurosurgical evaluation first? Do you require any patients to wear a neck brace?

1 Answer available

What are some alternatives to dexamethasone for brain edema in patients who are allergic, have an intolerance, or refuse the medication?

5 Answers available

How would you approach treatment of a brainstem AVM after hemorrhage in a patient not a candidate for surgery or embolization?

What would be your preferred technique and dose/fractionation?

2 Answers available

What is the appropriate workup and treatment for patients with SMART syndrome following radiation for brain tumors?

For stroke-like migraine attacks after radiation therapy (SMART syndrome), does your management of these patient's change with recurrent episodes? How...

1 Answer available

Do you ever use bevacizumab in combination with standard radiation and temozolomide in the first-line setting for patients with glioblastoma?

If so, when do you consider this?

1 Answer available

How do you manage a symptomatic meningioma and associated vasogenic edema in a poor performance status patient?

Is there any additional benefit to radiation in addition to steroids in a patient who is not a surgical candidate?

2 Answers available

How do you manage multiple cavernous malformations that have bled and enlarged over time?

1 Answer available

How do you counsel patients on control of glioma-related seizures following radiation?

2 Answers available

How do you approach treatment of 1p19q non-codeleted high grade gliomas?

Has the recently published interim analysis of the CATNON trial altered your utilization of temozolomide? Does IDH status change your treatment appro...

1 Answer available

Is it ever appropriate to omit temozolomide in unmethylated glioblastoma?

Do you consider the small, but statistically significant, improvement in OS to outweigh the side effects of treatment?

3 Answers available

How do you approach treatment of a glioblastoma in pregnancy?

3 Answers available

In a healthy patient >65 years of age with glioblastoma multiforme, what is the recommendation for temozolomide when given concurrently with adjuvant radiation therapy?

Length of temozolomide course when given with adjuvant radiotherapy

1 Answer available

How would you manage leptomeningeal disease of the spine in the setting of prior WBRT?

What factors play into your decision whether to re-treat the brain with craniospinal radiotherapy vs irradiation of the spine only vs other measures (...

1 Answer available

In what situations would you consider memantine when treating multiple brain metastases with SRS?

1 Answer available

What is the optimal management for a patient with Tourette Syndrome with severe tics that preclude the patient from lying still for radiation?

E.g. The case in question is for a patient planned for thoracic RT for LS-SCLC. Any medications that may help or just give much bigger expansions to c...

1 Answer available

How do you approach treatment of a spinal meningioma?

When do you favor RT? What is your preferred dose/fractionation?

1 Answer available

How do you do approach treatment of a recurrent gliosarcoma?

How does length of time from prior chemoradiotherapy influence your management?

1 Answer available

How do you manage cranial radiotherapy in the setting of an acute CVA?

In a palliative setting, how long would you wait to initiate WBRT?

1 Answer available

Papers discussed in this category

Stroke, 2008 Jul 17

Establishing final infarct volume: stroke lesion evolution past 30 days is insignificant.

J Neuroimaging, 2020 Feb 10

From "Time is Brain" to "Imaging is Brain": A Paradigm Shift in the Management of Acute Ischemic Stroke.

The New England journal of medicine, 2014-02-20

A randomized trial of bevacizumab for newly diagnosed glioblastoma.

The New England journal of medicine, 2014-02-20

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.

Neuro-oncology, 2016-09

Upfront bevacizumab may extend survival for glioblastoma patients who do not receive second-line therapy: an exploratory analysis of AVAglio.

Onco Targets Ther, 2017 Jan 18

Add-on bevacizumab can prevent early clinical deterioration and prolong survival in newly diagnosed partially resected glioblastoma patients with a poor performance status.

Journal of neurosurgery, 2005-09

Acute neurological complications following gamma knife surgery for vestibular schwannoma. Case report.

Surgical neurology, 2000-05

Acute complications following gamma knife radiosurgery are rare.

Cureus, 2020 Jun 11

Vestibular Migraine Following Radiosurgery for Vestibular Schwannoma.

Stereotact Funct Neurosurg, 2019 Nov 26

Symptomatic Post-Radiosurgery Intratumoral Hemorrhage in a Case of Vestibular Schwannoma: A Case Report and Review of the Literature.

N Engl J Med,

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma.

Acta Oncol, 2015 Oct 23

Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer.

Int J Radiat Oncol Biol Phys, 2020 Jun 13

Is There a Role for Hypofractionated Thoracic Radiation Therapy in Limited-Stage Small Cell Lung Cancer? A Propensity Score Matched Analysis.

Neuro-oncology, 2013-10

Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial.

Acta Neurochir (Wien), 2019 Jan 29

Influence of pregnancy on glioma patients.

J. Clin. Oncol., 2020 Feb 14

Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.

Cancer, 2020 May 19

Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy.

N Engl J Med,

MGMT gene silencing and benefit from temozolomide in glioblastoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-09-01

Randomized trial of radiation therapy plus procarbazine, lomustine, and vincristine chemotherapy for supratentorial adult low-grade glioma: initial results of RTOG 9802.

Lancet Oncol, 2021 May 14

Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study.

Strahlenther Onkol,

Temozolomide combined with irradiation as postoperative treatment of primary glioblastoma multiforme. Phase I/II study.

J Clin Oncol, 2012 Oct 15

Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.

International journal of radiation oncology, biology, physics, 2018-06-01

Radiation-Induced Edema After Single-Fraction or Multifraction Stereotactic Radiosurgery for Meningioma: A Critical Review.

Surgical neurology international, 2018

Role of bevacizumab for treatment-refractory meningiomas: A systematic analysis and literature review.

J Neurooncol, 2019 Oct 01

WHO grade of intracranial meningiomas differs with respect to patient's age, location, tumor size and peritumoral edema.

Progress in neurological surgery, 2013

Stereotactic radiosurgery guidelines for the management of patients with intracranial cavernous malformations.

Neurosurgery,

Fractionated stereotactic radiotherapy for the treatment of large arteriovenous malformations with or without previous partial embolization.

Journal of neurosurgery. Spine, 2010-09

Reliability analysis of the epidural spinal cord compression scale.

Spine, 2010-10-15

A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group.

Neurosurgery,

Strategies to Mitigate Toxicities From Stereotactic Body Radiation Therapy for Spine Metastases.

Cancer, 2011 Feb 01

Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.

JAMA, 2017-12-19

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial.

J Clin Oncol, 2021 Dec 13

Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.

The New England journal of medicine, 2018-08-23

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain.

Lancet Oncol, 2020 Apr 03

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial.

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