Medical Oncology

CNS Disease

Questions discussed in this category

Is it safe to give large fraction stereotactic irradiation for brain metastases concurrently with VEGF inhibitors?

1 Answer available

Would you use T-DXd or capecitabine/trastuzumab/tucatinib for HER2+ metastatic breast cancer with predominantly CNS progression after THP?

Which regimen is preferred in second line for these patients? What is the efficacy of TDXd vs tucatinib in CNS metastases?

3 Answers available

Are there any circumstances in which you would recommend adjuvant chemoradiation for resected olfactory neuroblastoma?

4 Answers available

How do you approach the treatment of de novo, brain only metastatic HER2 positive breast cancer?

1 Answer available

Papers discussed in this category

N. Engl. J. Med., 2019 Dec 11

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer.

J Clin Oncol, 2020 May 29

Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial.

N Engl J Med,

Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer.

N Engl J Med, 2019 Dec 11

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.

Int. J. Radiat. Oncol. Biol. Phys., 2011 Jun 15

Esthesioneuroblastoma: is there a need for elective neck treatment?

Cancer, 2004-12-01

Sinonasal malignancies with neuroendocrine differentiation: patterns of failure according to histologic phenotype.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-09-20

Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update.

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