Is it safe to give large fraction stereotactic irradiation for brain metastases concurrently with VEGF inhibitors?

Topics: Radiation Oncology • Palliation • Neuro-Oncology • Medical Oncology • CNS Disease • Drug Toxicity

Answer from: Medical Oncologist at Academic Institution

Currently, this remains an unanswered question with limited prospective data. Historically, when we have given radiation, the TKIs have typically been held both before and after the radiation to decrease the risk of necrosis. Anecdotally, treatment with TKI peri-radiation has been associated with d...

Comments

Radiation Oncologist at University of Rochester
In general, most systemic agents do not appear to ...

Radiation Oncologist at University of Washington School of Medicine
I typically will ask med onc to hold VEGF and EGFR...

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