Would you use upfront immunotherapy in a patient with MSI high metastatic colon cancer in the setting of high volume disease?

Topics: Gastrointestinal Cancers • Medical Oncology

Bulky hepatic metastasis

Answer from: Medical Oncologist at Community Practice

Yes, based on results from KEYNOTE-177 with improved outcomes, including improved response rates, when Keytruda was compared to chemotherapy, I favor using single agent IO in these patients regardless of tumor burden.

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Medical Oncologist at Florida Cancer Specialists and Research Institute
How do you use it in oligometastatic disease, in t...

Answer from: Medical Oncologist at Academic Institution

These are challenging. I have used triplet in a couple of these who needed quick cytoreduction and for purposes on neoadjuvant for possible liver resection given the 30 percent primary refractory.

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Medical Oncologist at University of Vermont
I have not had this scenario come up in my practic...

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