Would you ever omit adjuvant therapy for rectal cancer in patients who underwent primary resection (TME), without any neoadjuvant therapy?
What about T3N0 disease? Would you use a recurrence score to help inform decisions?
Answer from: Medical Oncologist at Community Practice
For T3 and T4 tumors and those that have radiographic or EUS staged lymph node involvement, pre-operative therapy is the prefered approach.
For patients with Stage I disease (lymph node negative T1/T2 tumors), I would not recommend adjuvant therapy. While most of the trials that explored this quest...