Topics:
Gastrointestinal Cancers • Medical Oncology • Neuroendocrine Tumors • NCI-CCC Tumor Board Question • Mayo Clinic • NCI-CCC Neuroendocrine Tumor Board
Would you consider PRRT re-treatment in a patient with a well differentiated NET previously treated with 4 cycles of PRRT?
Answer from: Medical Oncologist at Academic Institution
Yes, but only for highly selected patients. Might consider discussing retreatment with PRRT (R-PRRT) in those who: 1. Derived good response (or prolonged stable disease) with prior PRRT and,2. Don't have better options available (for example, would not do R-PRRT before CapTem, afinitor, su...
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Answer from: Medical Oncologist at Academic Institution
I agree with the above. Of course, quality data (in the form of RCTs) are lacking when it comes to retreatment with PRRT (rPRRT). We have typically selected patients where other therapy options are lacking, where the tumors still have a substantial and uniform somatostatin receptor expression, and w...