Would you consider lenvatinib plus everolimus as first line treatment for a patient with tuberous sclerosis and metastatic renal cell carcinoma?
Answer from: Medical Oncologist at Academic Institution
TL;DR: Yes, that would be very reasonable.Based on the CLEAR study, the combination of lenvatinib and everolimus has shown improved ORR and PFS compared to sunitinib. However, based on RECORD-3, which everolimus was inferior to sunitinib in an intent to treat population and in a mTOR pathway activat...