When would you consider initial induction chemotherapy (e.g. FOLFOX) followed by neoadjuvant chemoradiation, over neoadjuvant chemoradiation alone, in patients with locally advanced rectal cancer?
Answer from: Medical Oncologist at Community Practice
I think about using induction chemotherapy for larger, bulkier tumors; extensive radiographic evidence of nodal involvement; or those with encroachment into other organs for which margins may be an issue at the time of surgery. This approach is being formally studied on the PROSPECT trial&...
Sign in or Register to read more
Answer from: Radiation Oncologist at Academic Institution
At MSKCC, we now routinely recommend induction chemotherapy (8 cycles of FOLFOX) to any rectal cancer patient who requires preoperative chemoRT. Initially, we adopted this approach for patients with particularly bulky or node-positive disease (as per @Autumn J. McRee's answer above) but now do it fo...
Comments
Medical Oncologist at Cancer Care Specialists/Renown Oncology/UNR
Will you skip chemo XRT if they achieve good trea...
Will you skip chemo XRT if they achieve good trea...
Radiation Oncologist at Memorial Sloan Kettering Cancer Center
No, we would not offer that, and we emphasize to p...
No, we would not offer that, and we emphasize to p...
Medical Oncologist
When would you consider watch and wait following s...
When would you consider watch and wait following s...