What is your preferred second-line of treatment for metastatic gallbladder carcinoma after progression on gemcitabine/cisplatin in a young, fit patient?
Answer from: Medical Oncologist at Community Practice
There is currently no standard of care for second-line therapy in biliary tract cancers after front-line cisplatin/gemcitabine. During front-line therapy, I routinely send these tumors for molecular profiling, as targetable mutations are relatively common in biliary tract cancers and differ ba...
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Answer from: Medical Oncologist at Community Practice
Beside a clinical study, my 2nd line preference is FOLFOX. This is based on the results of UK's ABC-06 trial. This was a randomized Phase III study of FOLFOX with active symptom control (ASC) vs ASC alone in patients with locally advanced/metastatic bile tract cancer previously trea...