Topics:
Thoracic Malignancies • Medical Oncology
What factors might influence your initial treatment decision of oligometastatic NSCLC assuming good performance status, lack of actionable mutation, and PD-L1 status < 50%?
Would you consider "aggressive" concurrent chemoradiation followed by SRS to the CNS lesion and possible consolidative immunotherpay (the PACIFIC approach) or would you consider triplet with platinum-doublet/immunotherapy (Keynote-189 approach)?
Answer from: Medical Oncologist at Academic Institution
I would suggest that the biology of a "precocious" metastasis, such as a solitary brain or adrenal met that can be associated with patients doing well and even potentially being cured and without evidence of disease years after definitive local therapy to the primary tumor and solitary metastasis, i...
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