I have seen small amounts of evidence for V4<20cc and V14<7cc, but overall it seems like there is little published on this issue.
New comment by Radiation Oncologist at Karmanos Cancer Institute - McLaren Proton Therapy Center ( October 22, 2021)
Thanks Dr. @Christine N. Chang-Halpenny, those are nice articles with solid constraints!
If unable to meet those for a multiple metastases patient, I would reduce any PTV mar...