Is it safe to irradiate a patient with Cowden syndrome?  

In an asymptomatic patient, would this be safe?

Is there any reason to withhold radiation such as in case of T1N0 breast cancer advising patient to not do breast conservation but instead get mastectomy?

I’ve only found two case reports- one in which this was very toxic https://www.redjournal.org/article/S0360-3016(17)33150-4/fulltext
And the other in which no mention of toxicity is made (http://www.jnccn.org/content/13/11/1310.full.pdf). Wondering if anyone knows of other series or has personal experience in terms of toxicity, tolerance and potential late effects.



Answer from: Radiation Oncologist at Community Practice

Answer from: Radiation Oncologist at Community Practice
Comments
Radiation Oncologist at Queens Hospital Center (Icahn School of Medicine at Mount Sinai)
I irradiated 1 patient with breast cancer and Cowd...
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