It isn't clear from the way the question is asked whether this (real or hypothetical) elderly patient is not a surgical candidate due to the extent of her disease (locally advanced) or due to medical comorbidities. However, in either case my answer would be the same, unless her medical condition is ...

Treatment decisions for these patients can best be made based on geriatric assessment, estimated life expectancy, whether the treatment goal is prolonged survival or palliation, the potential benefits and toxicities of a specific treatment, and the patient’s personal goals for treatment. The n...