Topics:
Radiation Oncology • Neuro-Oncology
How do you manage disease progression during adjuvant chemoradiotherapy for glioblastoma?
Under what circumstances would you discontinue or alter therapy?
Answer from: Radiation Oncologist at Academic Institution
Hospice.
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Answer from: Radiation Oncologist at Community Practice
I agree with @Theodore E. Yaeger. This is not a “single best answer” question.
First, I’ll pose a question of my own: do you check the “radical” or “palliative” box in your prescription? I have never had a patient achieve permanent NED status, so I view our...
Answer from: Radiation Oncologist at Academic Institution
How are you defining disease progression during chemoradiation? If just radiographic, I would treat on. If clinical, I would consider transitioning to hypofrac (if not already doing so) and completing treatment.
If very early on in the course, and disease is resectable (say early recurrence between...
Answer from: at Academic Institution
As a clinical practice matter, I strongly doubt true progression during chemoradiation therapy and have no "stronger" treatment options that would be more cytocidal. I typically manage symptoms and proceed with the planned course of RT.Radiographic progression during treatment is expected and reflec...