How do you approach treatment for solitary fibrous tumor with a multifocal pleural-based metastatic recurrence that is surgically inoperable in a patient with good performance status?
How, if any, do you utilize genomic testing to guide systemic therapy?
Answer from: Medical Oncologist at Academic Institution
Standard sarcoma chemotherapy does NOT work unless SFT has dedifferentiated into a frank sarcoma. For SFT, VEGFR inhibition helps. Options tested are temozolomide/bevacizumab (Park, et al. Cancer 2011), sunitinib or pazopanib.
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Answer from: Medical Oncologist at Academic Institution
In addition to the options put forth by @Shreyaskumar Patel, there is a retrospective describing activity of trabectedin for SFT: Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group.I have had some luck with trabectedin.There is a case...