In case of primary or dominant urothelial carcinoma with squamous cell features, would approach similar to pure urothelial carcinoma and consider same radio-sensitizing chemo that we are using in S1806 phase III trial. Doses below may not fully reflect S1806 protocol and also depends on the patient ...

While data for pure non-urothelial histology and trimodality therapy (TMT) are lacking, a retrospective study suggests that variant urothelial carcinoma (VUC, urothelial carcinoma with other histologic components except small-cell) exhibits similar outcomes when compared with pure urothelial carcino...