Topics:
Radiation Oncology • Neuro-Oncology
Do you offer hypofractionated courses of radiation with temozolomide for "elderly" patients with GBM?
Does the MGMT status change your decision-making? Should we be routinely testing MGMT for elderly patients?
Answer from: Radiation Oncologist at Academic Institution
The ASTRO GBM guideline states the following with regard to elderly patients:
“Given the absence of proven superiority for conventionally fractionated radiation therapy, the panel recommends hypofractionated radiation therapy for elderly patients with fair-good performance status (high qualit...
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Answer from: Radiation Oncologist at Academic Institution
This question has been asked in a randomized clinical trial, "A phase III randomized controlled trial of short-course radiotherapy with or without concomitant and adjuvant temozolomide in elderly patients with glioblastoma" and will be presented at the ASCO Annual Meeting Plenary Session by James Pe...
Answer from: Radiation Oncologist at Academic Institution
Yes, we do offer hypofractionated RT for elderly GBM patients off trial.