Do you alter your management of Stage I-II DLBCL if it's double or triple hit?
Specifically, do you utilize 3 cycles of chemo with ISRT or 6 cycles? Do you use R-EPOCH or R-CHOP in these cases?
Answer from: Medical Oncologist at Community Practice
True early stage Double Hit DLBCL do not show the same high risk prognosis compared to advance stage DLBCL. Two studies support this. Note the DH population is small and the second paper looked at COO.https://www.ncbi.nlm.nih.gov/pubmed/31285189https://www.ncbi.nlm.nih.gov/pubmed/26456939I would qua...