Rheumatology

Systemic sclerosis

Questions discussed in this category

How do you mitigate the risk of renal crisis from corticosteroids in a patient with UCTD?

1 Answer available

Is there a role for cyclophosphamide in refractory digital ischemia in patients with scleroderma?

1 Answer available

Is nailfold capillaroscopy useful for prognostication and evaluation of disease progression in MCTD/myositis patients?

1 Answer available

Is there a role for IVIG in the treatment of active morphea refractory to immunosuppressive agents?

1 Answer available

Does calcinosis appear differently in patients with dermatomyositis compared to systemic sclerosis?

1 Answer available

How do you utilize methotrexate and/or hydroxychloroquine in the setting of limited scleroderma/CREST?

1 Answer available

In the absence of lung disease, do you prefer methotrexate or mycophenolate mofetil in the initial treatment of cutaneous-only manifestations in systemic sclerosis?

2 Answers available

Is nailfold capillaroscopy useful for prognostication and evaluation of disease progression in scleroderma patients?

1 Answer available

How do you approach the use of endothelin receptor antagonists in patients with scleroderma renal crisis and hypertension refractory to maximum ACE inhibition and calcium channel blockers?

1 Answer available

For patients with scleroderma at high risk of renal crisis, would you feel comfortable giving corticosteroids as pre-medication for rituximab?

1 Answer available

How do you approach the use of steroids for active muscle disease in patients with scleroderma-myositis overlap syndromes?

1 Answer available

How do you approach infused prostacyclin therapy for critical digital ischemia?

What factors go into choosing the right patient and determining length of therapy?

1 Answer available

How do you approach the management of SSc-ILD in a patient on immune checkpoint therapy?

1 Answer available

Are there scenarios where you send additional antibodies beyond anti-centromere, Scl-70, and RNA polymerase III in suspected scleroderma patients?

1 Answer available

How do you approach immunosuppression targeting skin thickening in scleroderma after the initial three years of onset?

(Skin thickening in the absence of visceral disease)

1 Answer available

How will you use tocilizumab in the treatment algorithm for SSc-ILD, given its recent FDA approval?

1 Answer available

How do you treat Raynaud's in patients with baseline low blood pressure?

1 Answer available

Is there a role for anti-IL6 therapy in SSc-associated ILD?

1 Answer available

What's the best treatment for calcinosis universalis in a scleroderma patient?

1 Answer available

How do you manage severe Raynaud's phenomenon with ulceration in scleroderma patients that is refractory to oral agents (CCBs, PDEis, ARBs, and ERAs)?

2 Answers available

What is the role of nintedanib in the treatment of SSc-ILD?

The SENSCIS trial was published in 2019 on efficacy of this agent. However, it's not clear where this should be in the treatment algorithm: Monot...

2 Answers available

When is it appropriate to refer a systemic sclerosis patient for bone marrow transplant evaluation?

2 Answers available

Papers discussed in this category

The New England journal of medicine, 2018-01-04

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.

N. Engl. J. Med., 2019 May 20

Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.

The Lancet. Respiratory medicine, 2016-09

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.

The New England journal of medicine, 2006-06-22

Cyclophosphamide versus placebo in scleroderma lung disease.

Autoimmun Rev, 2019 Sep 11

Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern".

Clin Exp Rheumatol, 2020 Aug 26

Consensus-based evaluation of dermatoscopy versus nailfold videocapillaroscopy in Raynaud's phenomenon linking USA and Europe: a European League against Rheumatism study group on microcirculation in rheumatic diseases project.

Microvasc Res, 2016 Sep 07

Capillary density: An important parameter in nailfold capillaroscopy.

J Rheumatol, 2019 Aug 15

Nailfold Videocapillaroscopy in Systemic Sclerosis-related Pulmonary Arterial Hypertension: A Systematic Literature Review.

The British journal of dermatology, 2019-11

Utilization patterns and performance of commercial myositis autoantibody panels in routine clinical practice.

Front Med (Lausanne), 2021 Aug 10

Nailfold Capillaroscopy Abnormalities Correlate With Disease Activity in Adult Dermatomyositis.

Autoimmun Rev, 2022 Apr 12

Standardised interpretation of capillaroscopy in autoimmune idiopathic inflammatory myopathies: A structured review on behalf of the EULAR study group on microcirculation in Rheumatic Diseases.

Clin Rheumatol, 2014 Oct 17

Nailfold capillaroscopic changes in dermatomyositis and polymyositis.

Clin Rheumatol, 2019 Aug 22

Nailfold videocapillaroscopy alterations in dermatomyositis, antisynthetase syndrome, overlap myositis, and immune-mediated necrotizing myopathy.

Reumatologia, 2022 Feb 28

Nailfold capillaroscopy changes with disease activity in patients with inflammatory myositis including overlap myositis, pure dermatomyositis, and pure polymyositis.

Rheumatology (Oxford), 2022 Mar 14

Nailfold microvascular abnormalities are associated with a higher prevalence of pulmonary arterial hypertension in patients with MCTD.

Lancet Respir Med, 2020 Aug 28

Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.

Arthritis Rheumatol, 2021 Feb 03

Tocilizumab Prevents Progression of Early Systemic Sclerosis Associated Interstitial Lung Disease.

Semin Arthritis Rheum,

Autoantibodies in systemic sclerosis.

Ann Rheum Dis, 2016 Nov 09

Update of EULAR recommendations for the treatment of systemic sclerosis.

QJM, 2013 May 21

Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility.

Eur J Dermatol,

Response of recalcitrant generalized morphea to intravenous immunoglobulins (IVIg): three cases and a review of the literature.

Case reports in rheumatology, 2017

A Rare Case of Digital Ischemia and Gangrene in ANCA-Associated Vasculitis with Review of the Literature.

Rheumatology

Systemic sclerosis

Questions discussed in this category

Papers discussed in this category

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