Pediatric Oncology

Neuro-Oncology

Questions discussed in this category

Why do we use dexamethasone for CNS edema and prednisone for pneumonitis?

Is this an artifact of what agent prior clinical trials used or something to do with mechanism of action (ie less mineralocorticoid effect of dex)?

1 Answer available

What are some alternatives to dexamethasone for brain edema in patients who are allergic, have an intolerance, or refuse the medication?

5 Answers available

Should all pediatric CNS cases be referred to a proton center?

If not, how should you select those cases that should be referred?

4 Answers available

How do you treat a primary pineal neoplasm of intermediate differentiation?

Would extent of surgical resection matter? Do these patients need CSI (like Pineoblastoma), just local radiation, or something in-between (say whole ...

2 Answers available

How do you approach treatment of a glioblastoma in pregnancy?

3 Answers available

Is placing a VP shunt a major risk to spread medulloblastoma or other malignant brain tumors into the gut?

1 Answer available

Should special precautions be taken patients with Ehlers-Danlos syndrome receiving radiation therapy?

Would you have reservations in treating patients with breast, GI, or pelvic malignancies with radiation alone or concurrent chemoradiation?

2 Answers available

How would you manage an unresectable central meningioma in a young patient with evidence of mild compression on the optic nerve and 4th ventricle involvement?

1 Answer available

When would you consider radiation therapy for an optic pathway glioma in a pediatric patient?

0 Answers available

Should adjuvant maintenance chemotherapy be provided to children with anaplastic ependymoma following radiation therapy?

Utility of maintenance chemotherapy per ACNS0831 in patients with anaplastic ependymoma

1 Answer available

What treatment approach do you take in a pediatric patient less than 3 years old with malignant papillary epithelioid tumor within the pineal region?

1 Answer available

When do you offer hyperbaric oxygen therapy to a pediatric brain tumor patient with radiation injury/necrosis?

1 Answer available

How do you approach treatment in an infant with metastatic atypical teratoid/rhabdoid tumor (ATRT) of the brain?

1 Answer available

When would you consider obtaining tumor tissue in NF-1 associated pediatric low grade glioma?

1 Answer available

What is the role for adjuvant monoclonal antibody therapy with radiation for diffuse intrinsic pontine glioma?

Discuss the role of mAb in DIPG.

1 Answer available

What treatment would you offer a young pregnant woman with a symptomatic midline low grade glioma?

Discussion of treatment options for midline low-grade glioma causing life-altering symptoms in a pregnant patient to avoid teratogenicity.

2 Answers available

What neoadjuvant, adjuvant chemotherapy regimen or targeted therapy can be used in paediatric patients with pelvic peripheral medulloepithelioma?

1 Answer available

Do you use hippocampal avoidance techniques when delivering PCI for high-risk leukemia?

1 Answer available

What is your preferred adjuvant chemotherapy for a pediatric patient less than 1 year old who had a gross total resection of a localized intracranial ependymoma, and will not be receiving radiation therapy due to his/her young age?

1 Answer available

What treatment do you offer to a pediatric patient with an optic pathway glioma with a BRAFV600E mutation who progressed despite receiving conventional chemotherapy, BRAF/MEK inhibitors, and radiation therapy?

1 Answer available

How do you manage a pediatric patient less than 3 years old with first relapse of medulloblastoma?

2 Answers available

Should post-op RT be delayed for children < 3yo after a GTR resection for a posterior fossa or supratentorial ependymoma?

1 Answer available

What is your approach when it comes to reirradiation for DIPG patients who have already received 54Gy upfront?

1 Answer available

Is there a role for hyperbaric oxygen treatment concurrent with radiotherapy in the treatment of pediatric glioblastoma?

1 Answer available

What is the value and potential morbidity of second look surgery in patients with sub-totally resected ependymoma?

1 Answer available

Papers discussed in this category

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-08-01

Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma.

Nature, 2014-02-27

C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-07-20

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Cancer cell, 2015-05-11

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

Neuro-oncology, 2016-07-01

Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling.

J. Radiat. Res., 2017-05-01

Radiotherapy using IMRT boosts after hyperbaric oxygen therapy with chemotherapy for glioblastoma.

J. Neurooncol., 2003-01-01

A phase II study of radiotherapy after hyperbaric oxygenation combined with interferon-beta and nimustine hydrochloride to treat supratentorial malignant gliomas.

Journal of neuro-oncology, 2012-01

Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience.

American journal of clinical oncology, 2012-02

Palliative reirradiation for progressive diffuse intrinsic pontine glioma.

Eur. J. Cancer, 2017-03-01

Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: A matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group.

Pediatric blood & cancer, 2018-08

Meta-analysis of the incidence and patterns of second neoplasms after photon craniospinal irradiation in children with medulloblastoma.

J. Pediatr. Hematol. Oncol.,

Presacral Medulloepithelioma: Case Report and Literature Review.

Neuro-oncology,

Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial.

Neuro-oncology, 2014-01

Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002-07-01

Phase II study of carboplatin in children with progressive low-grade gliomas.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-07-20

Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group.

J. Neurosurg., 2017 Mar 03

Interactions between glioma and pregnancy: insight from a 52-case multicenter series.

Acta Neurochir (Wien), 2019 Jan 29

Influence of pregnancy on glioma patients.

J. Neurooncol., 2018 Apr 06

Clinical challenges of glioma and pregnancy: a systematic review.

The Lancet. Oncology, 2018-08

Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial.

Journal of neuro-oncology, 2018-12

Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience.

J. Neurooncol., 2019 Mar 04

Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study.

Mol. Cancer Ther., 2016 Jun 20

Bevacizumab Targeting Diffuse Intrinsic Pontine Glioma: Results of 89Zr-Bevacizumab PET Imaging in Brain Tumor Models.

J. Neurooncol., 2017 Nov 15

Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma.

Neuro-oncology,

Implications of new understandings of gliomas in children and adults with NF1: report of a consensus conference.

Cancer Cell,

Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.

AJNR. American journal of neuroradiology, 1996-02

Induction and subsequent rupture of aneurysms of the circle of Willis after radiation therapy in Ehlers-Danlos syndrome: a plausible hypothesis.

J Clin Oncol, 2020 Feb 27

Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333.

Cancer Med, 2016 May 26

Improved 6-year overall survival in AT/RT - results of the registry study Rhabdoid 2007.

Pediatric emergency care, 2008-04

Clinical diagnosis of ventriculoperitoneal shunt failure among children with hydrocephalus.

Clin Nucl Med,

Extracranial Metastases From Glioblastoma With Primitive Neuronal Components on FDG PET/CT.

World J Surg Oncol, 2019 Mar 27

Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis.

Asian J Neurosurg,

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Neuro-oncology, 2017-01

Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.

Neurosurgery, 2002-07

Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors.

Practical radiation oncology, 2013

Importance of initial aggressive treatment for pineal parenchymal tumor of intermediate differentiation: A case report and review of literature.

Radiother Oncol, 2016 Nov 16

Patterns of care and survival outcomes in patients with pineal parenchymal tumor of intermediate differentiation: An individual patient data analysis.

Springerplus, 2016 Jan 12

Are we over treating Pineal Parenchymal tumour with intermediate differentiation? Assessing the role of localised radiation therapy and literature review.

J. Clin. Oncol., 2020 Feb 14

Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001.

Cancer, 2020 May 19

Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy.

Cancer, 2011 Feb 01

Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.

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