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Pediatric Oncology

Leukemia   

Questions discussed in this category

Which, if any, young/fit intermediate-risk AML patients would you not offer allogeneic transplant to in MRD- CR1?
1 Answer available
What is your institutional approach to a restrictive “neutropenic diet”?
3 Answers available
When would you consider additional testing for NUDT15 and other polymorphisms related to 6-MP/6-TG metabolism, if not guided by a study protocol?
2 Answers available
Is there any benefit to transplant patients with Ph+ ALL who have achieved MRD-negativity?
1 Answer available
What are your recommendations for a male patient who was recently started on imatinib and wants to conceive?
4 Answers available
How would you treat a pediatric or AYA patient with Ph-like ALL with induction failure?
1 Answer available
How do you approach conversations regarding discontinuation of transfusions in patients with advanced hematologic malignancies who are otherwise appropriate for hospice?
Are there other supportive care interventions that would otherwise be covered by hospice?
1 Answer available
In a patient with HR B ALL and severe pancreatitis due to peg-asparaginase, how do you assess the impact of peg discontinuation on risk of relapse?
For patients not on study, would you consider replacing missed doses of peg with a non-asparaginase based chemotherapy?
2 Answers available
What regimen would you offer a young patient with T-cell ALL who recurred a short time after allo-transplant and was initially treated with CALGB10403?
Especially with the current drug shortage of nelarabine.
2 Answers available
Would you start TKI therapy in a patient with new diagnosis of T-ALL without BCR-ABL gene rearrangement on FISH but found to have very low level p190 transcript on RT-PCR?
1 Answer available
What dose of PEG-asparaginase do you recommend for teens with high BMI treated on a pediatric ALL regimen?
Would you plan straight pediatric dosing using 2500 Units/m2 or a cap of 3750 Units as used in some adult ALL regimens due to excess liver/pancreas to...
2 Answers available
Is there data to support holding the 5th cycle of intensification for an AML patient with good prognosis and a history of significant infections and/or prolonged count recovery?
1 Answer available
Is a patient with secondary myeloid sarcoma a candidate for hematopoietic stem cell transplant?
2 Answers available
How do you choose chemotherapy for a pediatric patient with mixed-phenotype acute leukemia?
Patient's leukemia has both T and Myeloid lineages 
1 Answer available
How would you approach treatment in an otherwise young, fit patient with transformed AML currently in remission with a plan for transplant and was found to have an invasive fungal infection not amenable to resection upon recovery from induction?
Would you consider “bridging” therapy with something like an HMA?
1 Answer available
During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?
Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?
1 Answer available
What are the options of induction treatment of young AML patients who are on CRRT, continuous renal replacement therapy ?
1 Answer available
For pre-menopausal female patients who present with acute leukemia in need of urgent anti-neoplastic therapy, what is your preferred approach in effort to preserve fertility?
Does acute leukemia sub-type affect your decision? 
1 Answer available
When during ALL induction therapy are you checking for MRD?
1 Answer available
Do you offer fertility preservation to patients prior to CAR-T therapy?
Do you limit it to post-pubertal patients? Do you offer it only if they will proceed with bone marrow transplantation after CAR-T?
1 Answer available
When would you consider testicular RT prior to TBI for BMT?
What dose do you recommend?
1 Answer available


Papers discussed in this category

Cancer, 2004-08-15
The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation.
Br. J. Haematol., 2003-11-01
Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia.
Br. J. Haematol., 1998-08-01
Total body irradiation-high-dose cytosine arabinoside and melphalan followed by allogeneic bone marrow transplantation from HLA-identical siblings in the treatment of children with acute lymphoblastic leukaemia after relapse while receiving chemotherapy: a Société Française de Greffe de Moelle study.
Cancer, 1990-11-15
Testicular relapse in children with acute nonlymphoblastic leukemia.
Radiother Oncol, 1990-01-01
Total body irradiation for bone marrow transplantation: the Memorial Sloan-Kettering Cancer Center experience.
Fertil. Steril., 2013 Sep 05
Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion.
American journal of hematology, 2018-08
Description and prognostic significance of the kinetics of minimal residual disease status in adults with acute lymphoblastic leukemia treated with HyperCVAD.
Blood, 2019-04-04
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403.
Am. J. Hematol., 2019 Nov 19
The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia-negative B-cell acute lymphoblastic leukemia is a strong predictor for survival.
The New England journal of medicine, 2007-01-25
Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia.
Blood, 2018-07-19
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
, 2019 Oct 29
Mixed-phenotype acute leukemia: A cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force.
, 2018 Feb 27
Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis.
Clin Lymphoma Myeloma Leuk, 2017 Mar 07
Myeloid Sarcoma: Presentation, Diagnosis, and Treatment.
British journal of haematology, 2011-11
Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial.
Haematologica, 2020 Feb 6
Bortezomib with standard chemotherapy for children with acute myeloid leukemia does not improve treatment outcomes: a report from the Children's Oncology Group.
Leuk Lymphoma, 2019 Nov 04
Efficacy and toxicity of reduced vs. standard dose pegylated asparaginase in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-02-20
High-dose vincristine sulfate liposome injection for advanced, relapsed, and refractory adult Philadelphia chromosome-negative acute lymphoblastic leukemia.
Lancet (London, England), 2010-12-11
Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial.
Blood, 2012 Apr 04
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.
Clin Lymphoma Myeloma Leuk, 2019 Sep 30
Clinical Experience With Venetoclax Combined With Chemotherapy for Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia.
Bone Marrow Transplant, 2018 Jun 08
Daratumumab at the frontiers of post-transplant refractory T-acute lymphoblastic leukemia-a worthwhile strategy?
The Lancet. Oncology, 2017-09
Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study.
J Clin Oncol, 2020 Apr 10
Impact of Asparaginase Discontinuation on Outcome in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group.
Blood, 2008-02-15
In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993).
Blood, 2016-07-28
Impact of complete molecular response on survival in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Blood advances, 2016-12-27
US Intergroup Study of Chemotherapy Plus Dasatinib and Allogeneic Stem Cell Transplant in Philadelphia Chromosome Positive ALL.
The Lancet. Haematology, 2018-12
Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: long-term follow-up of a single-centre, phase 2 study.
N Engl J Med,
Dasatinib-Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults.
Pharmacogenomics,
Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe.
Pediatr Blood Cancer, 2011 Feb 22
A cost effectiveness analysis of thiopurine methyltransferase testing for guiding 6-mercaptopurine dosing in children with acute lymphoblastic leukemia.
Pediatr Blood Cancer, 2011 Jul 27
Pharmacogenetics, cost of genotyping, and guidelines for individualizing therapy with mercaptopurine in pediatric acute lymphoblastic leukemia.
Int J Hematol, 2021 Oct 28
NUDT15 genetic testing-guided 6-mercaptopurine dosing in children with ALL likely to be cost-saving in China.
Pharmacogenet Genomics,
Cost-effectiveness analysis of pretreatment screening for NUDT15 defective alleles.
Journal of hospital medicine, 2018-08-01
Things We Do For No Reason: Neutropenic Diet.

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