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Questions discussed in this category

Would you start anticoagulation in a patient with a history of CVA 1 year ago and high risk APL profile who was never started on anticoagulation, but is now presenting for follow up and without recurrent thrombotic events?
The patient has no known history of autoimmune disease.
4 Answers available
How will you treat a young man with recurrent cryptogenic strokes with no identifiable cause, with MTHFR A1298C homozygous mutation and normal homocysteine level?
0 Answers available
Do you always initiate hypercoagulable work up in a patient with recurrent stroke?
If so, what would you consider ordering?
1 Answer available
How would you approach protein S deficiency found on hypercoagulability work-up in a patient with a post-operative central retinal vein occlusion?
In the setting of no personal or family history and no other risk factors for thrombosis, is systemic anticoagulation warranted if local treatments (e...
4 Answers available
How long after starting anticoagulation would you remove an IVC filter in a patient with a DVT presenting with stroke and PFO which is now closed?
1 Answer available
What is your approach to a patient who has an ischemic stroke while on clopidogrel despite strict compliance and normal results on clopidogrel response assay?
5 Answers available
How does evidence of cerebral amyloid angiopathy/microbleeds affect choices for secondary stroke prevention in patients with a history of ischemic stroke and atrial fibrillation?
How do you approach secondary stroke prevention for patients with ischemic stroke, atrial fibrillation, and signs of cerebral amyloid angiopathy/micro...
1 Answer available
Is antiplatelet or anticoagulant therapy preferred for the secondary prophylaxis of cryptogenic stroke in a patient with underlying malignancy?
4 Answers available
How do you manage drug-induced thrombocytopenia when the implicated drug is essential?
e.g. DITP from eptifibatide after a cardiac intervention
1 Answer available
Do you recommend work up for POEMS and/or amyloidosis for IgM monoclonal gammopathies associated with neuropathy?
Can you expand on this by sharing exactly what this routine workup should include? What additional tests outside of evaluating for POEMS and amyloidos...
2 Answers available


Papers discussed in this category

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019-08
Treatment Approaches to Lacunar Stroke.
Stroke, 2021 Sep 14
Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities.
Stroke, 2015-03
Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis.
BMJ open, 2014-12-02
Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study.
Mayo Clin Proc,
Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management.
Neurol Sci, 2021 Sep 16
Paraproteinemia and neuropathy.
J Am Heart Assoc, 2020 Nov 23
Direct Oral Anticoagulants in Patients With Inherited Thrombophilia and Venous Thromboembolism: A Prospective Cohort Study.
Am J Hematol,
Protein S abnormalities: a diagnostic nightmare.
Cancer causes & control : CCC, 2010-03
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.
Atherosclerosis, 2001-06
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
The American journal of clinical nutrition, 2008-10
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
Circulation. Cardiovascular genetics, 2008-12
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012-01
Methylenetetrahydrofolate reductase (MTHFR) polymorphism A1298C (Glu429Ala) predicts decline in renal function over time in the African-American Study of Kidney Disease and Hypertension (AASK) Trial and Veterans Affairs Hypertension Cohort (VAHC).
Human genetics, 2012-05
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.
PeerJ, 2013
Integrating precision medicine in the study and clinical treatment of a severely mentally ill person.
Nature, 2016-08-18
Analysis of protein-coding genetic variation in 60,706 humans.

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