Hematology

Iron Homeostasis

Questions discussed in this category

When and how do you initiate therapeutic phlebotomy for patients with hereditary hemochromatosis without evidence of end-organ injury?

1 Answer available

How do you manage a patient with transfusion-dependent MDS with concurrent hemochromatosis requiring phlebotomy?

1 Answer available

Would you treat iron deficiency in post PV myelofibrosis if anemia is the predominant concern?

1 Answer available

How often should you repeat iron testing in patients with hemochromatosis, not on phlebotomy?

Patient with ferritin level <1000 ng/mL and no evidence of end-organ damage

1 Answer available

Can you use other iron formulations if a patient develops Stevens-Johnson Syndrome with ferumoxytol?

1 Answer available

How often do you follow ferritin and organ iron-deposition in a patient who has known hereditary hemochromatosis, but no current evidence of iron overload?

e.g. a genetic mutation picked up through a family member

1 Answer available

Is there any role for iron chelation in a patient with iatrogenic transfusion-induced iron overload such as in patients with end-stage kidney or liver disease?

Does transplant eligibility make a difference for management?

1 Answer available

When do you consider iron chelation in elderly patients with transfusion-dependent MDS?

1 Answer available

What could explain discordant iron studies?

For a patient with low ferritin, but high TSAT?

1 Answer available

What is the target ferritin level for patients with hereditary hemochromatosis and signs of end-organ damage?

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?

2 Answers available

Papers discussed in this category

American journal of hematology, 2008-08

Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.

Blood, 2010-07-22

How I treat hemochromatosis.

Am J Gastroenterol,

ACG Clinical Guideline: Hereditary Hemochromatosis.

American journal of hematology, 2016-01

How we diagnose and treat iron deficiency anemia.

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