Can docetaxel be safely given to patients with hyperbilirubinemia from Gilbert’s syndrome?
Is dose modification of docetaxel necessary with Gilbert's when giving TCHP?
Medical Oncologist
Docetaxel can be safely administered at full doses in patients with Gilbert's Syndrome. These patients usually have a variant in the UGT1A1 gene. While it can cause issues with some oncologic therapies (especially ones that rely on UGT-1A - the classic being irinotecan), it does not seem to affect t...